Introduction
CJC-1295 is a modified GHRH analog studied for effects on GH and IGF-I axes. The VialVibes catalog lists a no-DAC research form. DAC and no-DAC forms differ in half-life engineering; do not assume interchangeability without analytical confirmation.
Chemical and structural summary
Modified GHRH (1-29) analog research material, no DAC. CAS 863288-34-0 commonly referenced. Confirm form and mass on CoA.
| Catalog name | CJC-1295 (no DAC) |
|---|---|
| Category | GH Axis Research |
| CAS | 863288-34-0 |
| Molecular weight note | Approximately 3367 g/mol for no-DAC form (confirm lot CoA) |
| Documentation | Lot-specific CoA available on request |
Research history and background
Published clinical pharmacology studies examined long-acting CJC-1295 constructs (including DAC-related designs) for prolonged GH and IGF-I stimulation with preserved pulsatility in some reports. Mouse GHRH-knockout work has also been used to study growth endpoints.
Areas investigated in laboratory and preclinical research
The following themes appear in peer-reviewed literature. Inclusion here means the topic has been studied or reviewed scientifically - not that catalog materials are validated for any endpoint.
- GHRH receptor pathway research
- GH / IGF-I axis experimental pharmacology
- Comparison of long-acting GHRH analogs in published studies
Mechanisms discussed in the literature
As a GHRH analog, CJC-1295 is discussed for increasing GH secretion amplitude/duration depending on formulation. Literature on DAC-containing forms emphasizes albumin binding and extended action; no-DAC material should be interpreted on its own analytical identity.
Key published studies and reviews
Prefer primary literature. Open links in a new tab. Always read full papers for methods and limitations.
- Teichman SL, et al. (2006). Prolonged stimulation of GH and IGF-I secretion by CJC-1295, a long-acting GHRH analog, in healthy adults. J Clin Endocrinol Metab. PubMed 16352683.
- Ionescu M, Frohman LA. (2006). Pulsatile secretion of GH persists during continuous stimulation by CJC-1295. J Clin Endocrinol Metab. PubMed 17018654.
Known limitations and evidence gaps
Catalog no-DAC research material is not automatically equivalent to every CJC-1295 construct in published trials. Human pharmacology papers describe regulated study settings, not open use of RUO peptides.
Laboratory handling notes
General laboratory practice for lyophilized peptides includes cool, dry storage protected from moisture and light, careful reconstitution with appropriate research diluents, and documentation of lot numbers. See educational guides for process literacy - not product-specific validated stability claims.
- Storage and stability of lyophilized peptides
- Reconstitution best practices for laboratory use
- Reconstitution calculator (concentration and aliquot volume math)
- How to read a Certificate of Analysis
Regulatory status note
Materials sold by VialVibes are Research Use Only. They are not intended for human consumption, clinical administration, or veterinary use, and are not sold as FDA-approved drugs. Where the scientific literature discusses approved medicines or investigational drug programs involving the same active structure class, those regulated products remain distinct from RUO research reagents. See Research Use Only - what it means and the legal RUO policy.