Research reference only — not a catalog item
MOTS-c
Research context
Mitochondrial-derived peptide literature examines MOTS-c in cellular metabolic assays and mouse studies of skeletal-muscle signaling and metabolic regulation.
What has been studied
- Cell assays
- Mouse models
Lee et al. (2015) describe MOTS-c as a peptide encoded by a short open reading frame in mitochondrial 12S rRNA. The paper reports cellular assays of folate-cycle and AMPK-related metabolic signaling and mouse experiments that recorded insulin-sensitivity and body-composition measures, with skeletal muscle discussed as a main tissue context.
These labels restate the setting of the cited paper. They are not new findings and do not describe a catalog material.
Research model areas
- Cellular metabolic assays
- Mouse skeletal-muscle and metabolic models
Selected published literature
What remains uncertain
Limitations
Cellular and mouse metabolic findings do not establish human metabolic, exercise, or body-composition outcomes.
Model areas in the Body Explorer: Metabolic pathway models.